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LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18.
Wang, Wei-Guang; Li, Ao; Yan, Bing-Chao; Niu, Shu-Bin; Tang, Jian-Wei; Li, Xiao-Nian; Du, Xue; Challis, Gregory L; Che, Yongsheng; Sun, Han-Dong; Pu, Jian-Xin.
Afiliación
  • Wang WG; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
  • Li A; College of Pharmacy and Bioengineering, Chongqing University of Technology , Chongqing 400054, People's Republic of China.
  • Yan BC; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
  • Niu SB; University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
  • Tang JW; State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology , Beijing 100850, People's Republic of China.
  • Li XN; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
  • Du X; University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
  • Challis GL; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
  • Che Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, People's Republic of China.
  • Sun HD; Department of Chemistry, University of Warwick , Coventry CV4 7AL, United Kingdom.
  • Pu JX; State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology , Beijing 100850, People's Republic of China.
J Nat Prod ; 79(1): 149-55, 2016 Jan 22.
Article en En | MEDLINE | ID: mdl-26677752
ABSTRACT
Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-ß (TGF-ß)/Smad signaling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penicillium / Ácidos Carboxílicos / Furanos Límite: Animals Idioma: En Revista: J Nat Prod Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Penicillium / Ácidos Carboxílicos / Furanos Límite: Animals Idioma: En Revista: J Nat Prod Año: 2016 Tipo del documento: Article