An essential cell cycle regulation gene causes hybrid inviability in Drosophila.
Science
; 350(6267): 1552-5, 2015 Dec 18.
Article
en En
| MEDLINE
| ID: mdl-26680200
ABSTRACT
Speciation, the process by which new biological species arise, involves the evolution of reproductive barriers, such as hybrid sterility or inviability between populations. However, identifying hybrid incompatibility genes remains a key obstacle in understanding the molecular basis of reproductive isolation. We devised a genomic screen, which identified a cell cycle-regulation gene as the cause of male inviability in hybrids resulting from a cross between Drosophila melanogaster and D. simulans. Ablation of the D. simulans allele of this gene is sufficient to rescue the adult viability of hybrid males. This dominantly acting cell cycle regulator causes mitotic arrest and, thereby, inviability of male hybrid larvae. Our genomic method provides a facile means to accelerate the identification of hybrid incompatibility genes in other model and nonmodel systems.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Ciclo Celular
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Drosophila melanogaster
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Especiación Genética
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Aislamiento Reproductivo
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Drosophila simulans
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Genes Letales
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2015
Tipo del documento:
Article
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA