Cerebrospinal fluid markers of central nervous system injury in decompression illness - a case-controlled pilot study.
Diving Hyperb Med
; 45(4): 240-3, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26687311
ABSTRACT
INTRODUCTION:
Decompression sickness (DCS) may cause a wide variety of symptoms, including central nervous system (CNS) manifestations. The main objective of this study was to examine whether DCS is associated with neuronal injury, and whether DCS could result in altered amyloid metabolism.METHODS:
Seven, male divers with DCS and seven age-matched controls were included in the study. All the divers were treated by recompression but the controls did not receive hyperbaric oxygen. Cerebrospinal fluid (CSF) samples were collected 7-10 days after the diving injury and at three months follow-up. CSF biomarkers of neuronal injury, astroglial Injury/activation, and a range of markers of amyloid ß (Aß) metabolism, as well as two proinflammatory interleukins, were analysed using immunochemical methods.RESULTS:
There were no significant differences in the best-established CSF markers of neuronal injury, total tau (T-tau) and neurofilament light, between DCS patients and controls or between the two sampling time points. Also, there were no significant changes in the astroglial or amyloid (Aß)-related markers between DCS patients and controls. However, the only diver with CNS symptoms had the highest levels of CSF T-tau, Aß38, Aß40 and Aß42.CONCLUSION:
The results of our study speak against subclinical CNS injury or induction of inflammation or amyloid build-up in the brain among the six DCS patients without neurological symptoms. Further research, including on divers with CNS DCS, is justified.Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores
/
Sistema Nervioso Central
/
Enfermedad de Descompresión
/
Buceo
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Diving Hyperb Med
Año:
2015
Tipo del documento:
Article