Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA.

Duprey, Jean-Louis H A; Carr-Smith, James; Horswell, Sarah L; Kowalski, Jaroslaw; Tucker, James H R

Duprey, Jean-Louis H A; Carr-Smith, James; Horswell, Sarah L; Kowalski, Jaroslaw; Tucker, James H R.

Afiliación

Duprey JL; School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.
Carr-Smith J; School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.
Horswell SL; School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.
Kowalski J; Insitute of Organic Chemistry, Polish Academy of Sciences , Kasprzaka 44/52, Warsaw, 01-224, Poland.
Tucker JH; School of Chemistry, University of Birmingham , Edgbaston, Birmingham, West Midlands B15 2TT, U.K.

J Am Chem Soc ; 138(3): 746-9, 2016 Jan 27.

Article en En | MEDLINE | ID: mdl-26694542

ABSTRACT

ABSTRACT

The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.

Asunto(s)

ADN/química; Técnicas Electroquímicas; Compuestos Macrocíclicos/química; Nucleótidos/análisis; Compuestos Organometálicos/química; Estructura Molecular

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / ADN / Compuestos Macrocíclicos / Técnicas Electroquímicas / Nucleótidos Idioma: En Revista: J Am Chem Soc Año: 2016 Tipo del documento: Article País de afiliación: Reino Unido

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