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Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.
Fey, Dirk; Halasz, Melinda; Dreidax, Daniel; Kennedy, Sean P; Hastings, Jordan F; Rauch, Nora; Munoz, Amaya Garcia; Pilkington, Ruth; Fischer, Matthias; Westermann, Frank; Kolch, Walter; Kholodenko, Boris N; Croucher, David R.
Afiliación
  • Fey D; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
  • Halasz M; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
  • Dreidax D; Department of Neuroblastoma Genomics (B087), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Kennedy SP; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
  • Hastings JF; The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.
  • Rauch N; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
  • Munoz AG; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
  • Pilkington R; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.
  • Fischer M; Department of Pediatric Hematology and Oncology, University Hospital Cologne, 50937 Cologne, Germany. Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany. Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.
  • Westermann F; Department of Neuroblastoma Genomics (B087), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Kolch W; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
  • Kholodenko BN; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. d.crouche
  • Croucher DR; Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia. St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia. d.croucher
Sci Signal ; 8(408): ra130, 2015 Dec 22.
Article en En | MEDLINE | ID: mdl-26696630
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Transducción de Señal / Biomarcadores de Tumor / Proteínas Oncogénicas / MAP Quinasa Quinasa 4 / Modelos Biológicos / Neuroblastoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Sci Signal Asunto de la revista: CIENCIA / FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Nucleares / Transducción de Señal / Biomarcadores de Tumor / Proteínas Oncogénicas / MAP Quinasa Quinasa 4 / Modelos Biológicos / Neuroblastoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Sci Signal Asunto de la revista: CIENCIA / FISIOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos