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At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake venoms.
Mladic, Marija; Zietek, Barbara M; Iyer, Janaki Krishnamoorthy; Hermarij, Philip; Niessen, Wilfried M A; Somsen, Govert W; Kini, R Manjunatha; Kool, Jeroen.
Afiliación
  • Mladic M; Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands.
  • Zietek BM; Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands.
  • Iyer JK; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4 117543, Singapore.
  • Hermarij P; Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands.
  • Niessen WM; Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands; Hyphen MassSpec, Herenweg 95 2361, EK, Warmond, The Netherlands.
  • Somsen GW; Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands.
  • Kini RM; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4 117543, Singapore.
  • Kool J; Division of BioAnalytical Chemistry, Amsterdam Institute for Molecules Medicines and Systems, VU University Amsterdam, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands. Electronic address: j.kool@vu.nl.
Toxicon ; 110: 79-89, 2016 Feb.
Article en En | MEDLINE | ID: mdl-26708656
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Serpiente / Antitrombinas / Proteínas de Reptiles / Descubrimiento de Drogas / Inhibidores del Factor Xa Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Toxicon Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Serpiente / Antitrombinas / Proteínas de Reptiles / Descubrimiento de Drogas / Inhibidores del Factor Xa Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Toxicon Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido