HTLV-1, Immune Response and Autoimmunity.
Viruses
; 8(1)2015 Dec 24.
Article
en En
| MEDLINE
| ID: mdl-26712781
ABSTRACT
Human T-lymphotropic virus type-1 (HTLV-1) infection is associated with adult T-cell leukemia/lymphoma (ATL). Tropical spastic paraparesis/HTLV-1-associated myelopathy (PET/HAM) is involved in the development of autoimmune diseases including Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), and Sjögren's Syndrome (SS). The development of HTLV-1-driven autoimmunity is hypothesized to rely on molecular mimicry, because virus-like particles can trigger an inflammatory response. However, HTLV-1 modifies the behavior of CD4⺠T cells on infection and alters their cytokine production. A previous study showed that in patients infected with HTLV-1, the activity of regulatory CD4⺠T cells and their consequent expression of inflammatory and anti-inflammatory cytokines are altered. In this review, we discuss the mechanisms underlying changes in cytokine release leading to the loss of tolerance and development of autoimmunity.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus Linfotrópico T Tipo 1 Humano
/
Infecciones por HTLV-I
/
Autoinmunidad
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Viruses
Año:
2015
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND