The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line.

Xie, Jun; Liu, Jiahui; Liu, Heng; Liang, Shihui; Lin, Meigui; Gu, Yueyu; Liu, Taoli; Wang, Dongmei; Ge, Hui; Mo, Sui-Lin

Xie, Jun; Liu, Jiahui; Liu, Heng; Liang, Shihui; Lin, Meigui; Gu, Yueyu; Liu, Taoli; Wang, Dongmei; Ge, Hui; Mo, Sui-Lin.

Afiliación

Xie J; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Liu J; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Liu H; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Liang S; Huanghuagang Street Community Health Service Center, Guangzhou 510095, China.
Lin M; Liwan District Shiweitang Street Community Health Service Center, Guangzhou 510360, China.
Gu Y; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Liu T; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Wang D; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.
Ge H; Health Care and Physical Examination Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Mo SL; Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

Acta Pharm Sin B ; 5(6): 554-63, 2015 Nov.

Article en En | MEDLINE | ID: mdl-26713270

Palabras clave

ADM, adriamycin; CAM, chorioallantoic membrane; CCK-8, cell counting kit-8; DMSO, dimethylsulfoxide; EPCs, endothelial progenitor cells; FBS, fetal bovine serum; FCM, flow cytometry; HRP, horseradish peroxidase; IC50, 50% inhibitory concentration; MD, molecular dynamics; Molecular docking; NS, normal saline; NSCLC, non-small cell lung cancer; Non-small cell lung cancer; PI, propidium iodide; PKB/AKT, protein kinase B; RMSD, root-mean-square deviation; Tan IIA, tanshinone IIA; Tanshinone IIA; VEGF, vascular endothelial growth factor; VEGF/VEGFR signal pathway; mOS, median overall survival; tRR, tumor response rate; vdW, van der Waals force

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

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