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Analysis of Assembly and Budding of Lujo Virus.
Urata, Shuzo; Weyer, Jacqueline; Storm, Nadia; Miyazaki, Yukiko; van Vuren, Petrus Jansen; Paweska, Janusz Tadeusz; Yasuda, Jiro.
Afiliación
  • Urata S; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
  • Weyer J; Center for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases (NICD), Division of the National Health Laboratory Service, Sandringham, South Africa.
  • Storm N; Center for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases (NICD), Division of the National Health Laboratory Service, Sandringham, South Africa.
  • Miyazaki Y; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan The Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan.
  • van Vuren PJ; Center for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases (NICD), Division of the National Health Laboratory Service, Sandringham, South Africa.
  • Paweska JT; Center for Emerging and Zoonotic Diseases, National Institute for Communicable Diseases (NICD), Division of the National Health Laboratory Service, Sandringham, South Africa.
  • Yasuda J; Department of Emerging Infectious Diseases, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan The Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan j-yasuda@nagasaki-u.ac.jp.
J Virol ; 90(6): 3257-61, 2015 Dec 30.
Article en En | MEDLINE | ID: mdl-26719243
ABSTRACT
The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensamble de Virus / Liberación del Virus / Lujo virus Límite: Animals / Humans Idioma: En Revista: J Virol Año: 2015 Tipo del documento: Article País de afiliación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensamble de Virus / Liberación del Virus / Lujo virus Límite: Animals / Humans Idioma: En Revista: J Virol Año: 2015 Tipo del documento: Article País de afiliación: Japón