Systemic blood plasma CCL5 and CXCL6: Potential biomarkers for human lumbar disc degeneration.
Eur Cell Mater
; 31: 1-10, 2016 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-26728495
ABSTRACT
Lumbar disc degeneration severity on magnetic resonance imaging (MRI) is associated with low back pain. Pro-inflammatory chemokines CCL5 and CXCL6 are released by induced degenerative discs, and CCL5 has been associated with discogenic back pain. A case-control study was performed, based on the Hong Kong Disc Degeneration Population-Based Cohort of Southern Chinese, to investigate if systemic levels of CCL5 and CXCL6 were elevated in subjects with disc degeneration compared to non-degenerated individuals. Eighty subjects were selected, 40 with no disc degeneration (control group; DDD score 0) and 40 with moderate/severe disc degeneration (disc degeneration group; DDD score ≥5) as noted on MRI. Subjects were matched for age, sex, body mass index and workload. Blood plasma samples were obtained from each individual, and levels of CCL5 and CXCL6 were measured. Secondary phenotypes of lumbar disc displacement and cervical disc changes were also assessed. CCL5 concentrations were significantly increased in the disc degeneration (mean 19.8 ng/mL) compared to the control group (mean 12.8 ng/mL) (p = 0.015). The degeneration group demonstrated higher levels of CXCL6 (mean 56.9 pg/mL) compared to the control group (mean 43.4 pg/mL) (p = 0.010). There was a trend towards elevated CCL5 levels with disc displacement in the degeneration group (p = 0.073). Cervical disc degeneration was not associated with elevated chemokine levels (p > 0.05). This is the first study to note that elevated systemic CCL5 and CXCL6 were associated with moderate/severe lumbar disc degeneration, further corroborating tissue studies of painful discs. These chemokines may be systemic biomarkers for the diagnosis and monitoring of disc degeneration.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quimiocina CCL5
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Quimiocina CXCL6
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Degeneración del Disco Intervertebral
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Disco Intervertebral
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Desplazamiento del Disco Intervertebral
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Vértebras Lumbares
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Eur Cell Mater
Año:
2016
Tipo del documento:
Article