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Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo.
Kong, J; Chuddy, J; Stock, I A; Loria, P M; Straub, S V; Vage, C; Cameron, K O; Bhattacharya, S K; Lapham, K; McClure, K F; Zhang, Y; Jackson, V M.
Afiliación
  • Kong J; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Chuddy J; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Stock IA; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Loria PM; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Straub SV; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Vage C; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Cameron KO; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Bhattacharya SK; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Lapham K; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • McClure KF; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Zhang Y; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
  • Jackson VM; Cardiovascular and Metabolic Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA, 01239, USA.
Br J Pharmacol ; 173(9): 1452-64, 2016 May.
Article en En | MEDLINE | ID: mdl-26784385
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Espiro / Azetidinas / Nervio Vago / Receptores de Ghrelina / Agonismo Inverso de Drogas / Glucosa / Insulina Límite: Animals / Humans / Male Idioma: En Revista: Br J Pharmacol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Espiro / Azetidinas / Nervio Vago / Receptores de Ghrelina / Agonismo Inverso de Drogas / Glucosa / Insulina Límite: Animals / Humans / Male Idioma: En Revista: Br J Pharmacol Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido