Four cases of investigational therapy with interleukin-11 against acute myocardial infarction.
Heart Vessels
; 31(9): 1574-8, 2016 Sep.
Article
en En
| MEDLINE
| ID: mdl-26796134
We describe four cases of the patients with ST-elevation myocardial infarction (STEMI) that were treated with interleukin-11 (IL-11), a cardioprotective cytokine. Recombinant human IL-11 (rhIL-11), was intravenously administered to two cases at low dose (6 µg/kg) and to two at high dose (25 µg/kg). The cytokine administration started just after the coronary occlusion was confirmed by coronary angiography (CAG), taking 3 h. Following CAG, percutaneous coronary intervention (PCI) was performed as a standard therapy. No serious adverse drug reactions were observed. All the cases left the hospital without the symptom of heart failure. We discuss the possibility of the clinical use of rhIL-11 as an adjunct therapy to PCI for the STEMI patients.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cardiotónicos
/
Drogas en Investigación
/
Función Ventricular Izquierda
/
Interleucina-11
/
Infarto del Miocardio con Elevación del ST
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Heart Vessels
Asunto de la revista:
CARDIOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón