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Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial.
Mullan, Adam; Delles, Christian; Ferrell, William; Mullen, William; Edwards, Christine A; McColl, John H; Roberts, Susan A; Lean, Michael E; Sattar, Naveed.
Afiliación
  • Mullan A; Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow, Cardiovascular Research Centre, University of Glasgow, UK.
  • Delles C; Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow, Cardiovascular Research Centre, University of Glasgow, UK.
  • Ferrell W; Department of Physiology Institute of Immunity, Infection & Inflammation, University of Glasgow, UK.
  • Mullen W; Human Nutrition, School of Medicine, University of Glasgow, UK.
  • Edwards CA; Human Nutrition, School of Medicine, University of Glasgow, UK.
  • McColl JH; School of Mathematics and Statistics, University of Glasgow, UK.
  • Roberts SA; Global Scientific and Regulatory Affairs, The Coca-Cola Company, Atlanta, Georgia, USA.
  • Lean ME; Human Nutrition, School of Medicine, University of Glasgow, UK.
  • Sattar N; Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow, Cardiovascular Research Centre, University of Glasgow, UK. Electronic address: Naveed.Sattar@glasgow.ac.uk.
Atherosclerosis ; 246: 169-76, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26797134
OBJECTIVE: To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function in middle aged, overweight or obese subjects without medical co-morbidity in a randomized placebo controlled pilot study. METHODS: Randomly assigned active 250 ml beverages containing 361 mg of (poly)phenols and 120 mg of vitamin C or placebo (no polyphenol/vitamin C) were taken twice daily for 4 weeks. Both beverages contained 40 kcals/250 ml. The primary end-points were pulse wave velocity (PWV) and cutaneous microvascular responses to sodium nitroprusside (SNP) and acetyl choline (ACh) laser doppler iontophoresis. A range of established and novel plasma markers were also measured. RESULTS: Twenty subjects received active beverage and 19 placebo; all completed the study. There was no difference in cutaneous vascular response to either SNP or ACh with mean group differences (logΔ area under perfusion curve) of 0.30 (-0.65, 1.26) and 0.35 (-0.11, 0.81) respectively. Nor was there evidence of a change in log PWV with a mean group difference of 0.029 m/s (-0.042, 0.10). No significant differences were seen in plasma leptin, apolipoproteins, cystatin C, insulin, adiponectin, CRP, ICAM-1, E-Selectin or t-PA, but IL-6 increased in active versus placebo recipients (0.32 vs - 0.18 pg/ml; p=0.010). CONCLUSION: There was no evidence for a short-term beneficial effect of (poly)phenol intervention on microcutaneous vascular response or pulse wave velocity, and no evidence for a benefit on established or novel risk factors in overweight or obese subjects. Our results do not support a short-term benefit of (poly)phenol supplementation on cardiometabolic risk. REGISTRATION: Clinical Trials.gov (NCT00795834).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Enfermedades Vasculares / Flavonoides / Ácidos Cumáricos / Polifenoles / Hemodinámica / Obesidad Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Atherosclerosis Año: 2016 Tipo del documento: Article Pais de publicación: Irlanda

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Enfermedades Vasculares / Flavonoides / Ácidos Cumáricos / Polifenoles / Hemodinámica / Obesidad Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Atherosclerosis Año: 2016 Tipo del documento: Article Pais de publicación: Irlanda