Inflammatory mediators in human epilepsy: A systematic review and meta-analysis.
Neurosci Biobehav Rev
; 63: 177-90, 2016 Apr.
Article
en En
| MEDLINE
| ID: mdl-26877106
ABSTRACT
BACKGROUND:
Accumulating evidence suggests a role for inflammation in the pathophysiology of epilepsy.METHODS:
We performed a systematic review and meta-analysis of studies that investigated inflammatory mediators in human epilepsy. Studies reporting on inflammatory mediators in serum, cerebrospinal fluid or brain tissue of epilepsy patients were included. Studies comparing patients to controls were included in a meta-analysis.RESULTS:
66 articles reporting on 1934 patients were included. IL-1ra, IL-1ß, IL-6, IL-10, IFN-γ and TNF-α were the most extensively investigated proteins. Elevated levels for IL-1ra, IL-1ß, IL-6 and CXCL8/IL-8 were reported in several different epilepsy etiologies and media, while other proteins were specifically increased for one etiology. IL-1α, IL-7 and IL-13, as well as the chemokines CCL2-5, -19 and -22, were increased exclusively in brain tissue. In an aggregate meta-analysis, we found significantly different protein levels for serum IL-6, IL-17 and CSF IL-1ß and IL-10.CONCLUSION:
Inflammatory pathways are involved in epilepsy. Future studies may further clarify their role, and prove potential of targeted anti-inflammatory treatment.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Mediadores de Inflamación
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Epilepsia
/
Inflamación
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Neurosci Biobehav Rev
Año:
2016
Tipo del documento:
Article
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
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UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA