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Insertional Mutagenesis Identifies a STAT3/Arid1b/ß-catenin Pathway Driving Neurofibroma Initiation.
Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy.
Afiliación
  • Wu J; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Keng VW; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pediatrics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
  • Patmore DM; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Kendall JJ; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Patel AV; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Jousma E; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Jessen WJ; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Choi K; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Tschida BR; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
  • Silverstein KA; Biostatistics and Informatics, University of Minnesota, Minneapolis, MN 55455, USA.
  • Fan D; Biostatistics and Informatics, University of Minnesota, Minneapolis, MN 55455, USA.
  • Schwartz EB; Ohio State University, College of Pharmacy, Columbus, OH 43210, USA.
  • Fuchs JR; Ohio State University, College of Pharmacy, Columbus, OH 43210, USA.
  • Zou Y; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Kim MO; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Dombi E; Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
  • Levy DE; Department of Pathology and New York University Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
  • Huang G; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA.
  • Cancelas JA; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA; Hoxworth Blood Center, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
  • Stemmer-Rachamimov AO; Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
  • Spinner RJ; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA.
  • Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Department of Pediatrics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
  • Ratner N; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital University of Cincinnati, Cincinnati, OH 45229, USA. Electronic address: nancy.ratner@cchmc.org.
Cell Rep ; 14(8): 1979-90, 2016 Mar 01.
Article en En | MEDLINE | ID: mdl-26904939
Asunto(s)
Carcinogénesis/genética; Proteínas de Unión al ADN/genética; Regulación Neoplásica de la Expresión Génica; Acetiltransferasa A N-Terminal/genética; Neurofibromatosis 1/genética; Neoplasias del Sistema Nervioso Periférico/genética; Factor de Transcripción STAT3/genética; beta Catenina/genética; Animales; Carcinogénesis/metabolismo; Carcinogénesis/patología; ADN Helicasas/genética; ADN Helicasas/metabolismo; Proteínas de Unión al ADN/antagonistas & inhibidores; Proteínas de Unión al ADN/metabolismo; Modelos Animales de Enfermedad; Femenino; Glucógeno Sintasa Quinasa 3 beta/antagonistas & inhibidores; Glucógeno Sintasa Quinasa 3 beta/genética; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Histonas/genética; Histonas/metabolismo; Humanos; Ratones; Ratones Desnudos; Mutagénesis Insercional; Acetiltransferasa A N-Terminal/antagonistas & inhibidores; Acetiltransferasa A N-Terminal/metabolismo; Trasplante de Neoplasias; Células-Madre Neurales/metabolismo; Células-Madre Neurales/patología; Neurofibromatosis 1/metabolismo; Neurofibromatosis 1/patología; Neurofibromina 1/genética; Neurofibromina 1/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Neoplasias del Sistema Nervioso Periférico/metabolismo; Neoplasias del Sistema Nervioso Periférico/patología; Fosforilación; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Factor de Transcripción STAT3/antagonistas & inhibidores; Factor de Transcripción STAT3/metabolismo; Células de Schwann/metabolismo; Células de Schwann/patología; Transducción de Señal; Factores de Transcripción/genética; Factores de Transcripción/metabolismo; beta Catenina/metabolismo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Sistema Nervioso Periférico / Regulación Neoplásica de la Expresión Génica / Neurofibromatosis 1 / Proteínas de Unión al ADN / Factor de Transcripción STAT3 / Beta Catenina / Acetiltransferasa A N-Terminal / Carcinogénesis Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Rep Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Sistema Nervioso Periférico / Regulación Neoplásica de la Expresión Génica / Neurofibromatosis 1 / Proteínas de Unión al ADN / Factor de Transcripción STAT3 / Beta Catenina / Acetiltransferasa A N-Terminal / Carcinogénesis Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Rep Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos