Dengue virus non-structural 1 protein interacts with heterogeneous nuclear ribonucleoprotein H in human monocytic cells.
Asian Pac J Trop Med
; 9(2): 112-8, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26919938
ABSTRACT
OBJECTIVE:
To study protein-protein interaction between heterogeneous nuclear ribonucleoprotein H (hnRNP H) and Dengue virus (DENV) proteins.METHODS:
DENV proteins were screened against the host hnRNP H protein, in order to identify the host-viral protein-protein interactions in DENV infected THP-1 cells by co-immunoprecipitation. The co-localization of the interacting proteins was further confirmed by immunofluorescence microscopy.RESULTS:
The host protein hnRNP H was found to interact with DENV non-structural 1 protein and help the virus to multiply in the cell.CONCLUSIONS:
The non-structural 1 glycoprotein is a key modulator of host immune response and is also involved in viral replication. Therefore, disruption of this key interaction between hnRNP H and DENV non-structural 1 could be an important therapeutic strategy for management of DENV infection.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Asian Pac J Trop Med
Año:
2016
Tipo del documento:
Article
País de afiliación:
India