Sertoli Cell-Only Syndrome: Behind the Genetic Scenes.
Biomed Res Int
; 2016: 6191307, 2016.
Article
en En
| MEDLINE
| ID: mdl-26925412
ABSTRACT
Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. The aetiology often remains unknown. In this paper, we have investigated possible causes of Sertoli cell-only syndrome with a special focus on genetic causes. Our results show that, for a large part of the patients (>23% in an unselected group), the sex chromosomes are involved. The majority of patients had a Klinefelter syndrome, followed by patients with Yq microdeletions. Array comparative genomic hybridization in a selected group of "idiopathic patients" showed no known infertility related copy number variations.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Sólo Células de Sertoli
/
Variaciones en el Número de Copia de ADN
/
Infertilidad Masculina
/
Síndrome de Klinefelter
Tipo de estudio:
Etiology_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Biomed Res Int
Año:
2016
Tipo del documento:
Article
País de afiliación:
Bélgica