The Immunology of CD1- and MR1-Restricted T Cells.
Annu Rev Immunol
; 34: 479-510, 2016 05 20.
Article
en En
| MEDLINE
| ID: mdl-26927205
ABSTRACT
CD1- and MHC-related molecule-1 (MR1)-restricted T lymphocytes recognize nonpeptidic antigens, such as lipids and small metabolites, and account for a major fraction of circulating and tissue-resident T cells. They represent a readily activated, long-lasting population of effector cells and contribute to the early phases of immune response, orchestrating the function of other cells. This review addresses the main aspects of their immunological functions, including antigen and T cell receptor repertoires, mechanisms of nonpeptidic antigen presentation, and the current evidence for their participation in human and experimental diseases.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
/
Células Asesinas Naturales
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Activación de Linfocitos
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Receptores de Antígenos de Linfocitos T
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Células T Asesinas Naturales
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Infecciones
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Immunol
Año:
2016
Tipo del documento:
Article