The "&#960;-Clamp" Offers a New Strategy for Site-Selective Protein Modification.

Tharp, Jeffery M; Liu, Wenshe R

The "π-Clamp" Offers a New Strategy for Site-Selective Protein Modification.

Tharp, Jeffery M; Liu, Wenshe R.

Afiliación

Tharp JM; Department of Chemistry, Texas A&M University, College Station, TX, 77843, USA.
Liu WR; Department of Chemistry, Texas A&M University, College Station, TX, 77843, USA. wliu@chem.tamu.edu.

Chembiochem ; 17(10): 883-5, 2016 05 17.

Article en En | MEDLINE | ID: mdl-26928847

ABSTRACT

ABSTRACT

Pentelute and co-workers have identified a small encodable cysteine-containing peptide sequence that allows selective modification with perfluoroaryl probes. This π-clamp requires no external catalyst and is not limited to certain positions within a protein.

Asunto(s)

Proteínas/metabolismo; Biotina/química; Biotina/metabolismo; Catálisis; Cisteína/metabolismo; Fluorocarburos/química; Glutatión Transferasa/metabolismo; Procesamiento Proteico-Postraduccional; Proteínas/química

Palabras clave

cysteine; pi clamp; protein modification; site selectivity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Idioma: En Revista: Chembiochem Asunto de la revista: BIOQUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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