Systemic and renal effects of chronic angiotensin converting enzyme inhibition with captopril in hypertensive diabetic patients.
J Hypertens Suppl
; 7(7): S65-7, 1989 Sep.
Article
en En
| MEDLINE
| ID: mdl-2693660
Nine outpatients with mild to moderate arterial hypertension, type 2 diabetes mellitus and persistent macroalbuminuria were studied. After 1 month of placebo, the patients were treated with 50 mg captopril twice a day for the following 6 months. Blood pressure and urinary albumin excretion were significantly reduced but no relationship was found between these two variables. No changes were detected in the renal plasma flow, glomerular filtration rate, filtration fraction, renal vascular resistance or metabolic pattern. Captopril significantly reduced blood pressure and albuminuria without any change in the renal function. The decrease in albuminuria may be related to the reduction in blood pressure as well as to a direct effect of captopril on glomerular haemodynamics.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Captopril
/
Angiopatías Diabéticas
/
Hipertensión
/
Riñón
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Hypertens Suppl
Asunto de la revista:
ANGIOLOGIA
Año:
1989
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Reino Unido