The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease.
Neural Plast
; 2016: 3619274, 2016.
Article
en En
| MEDLINE
| ID: mdl-26942017
ABSTRACT
There is a growing body of evidence indicating that the mechanisms that control genome stability are of key importance in the development and function of the nervous system. The major threat for neurons is oxidative DNA damage, which is repaired by the base excision repair (BER) pathway. Functional mutations of enzymes that are involved in the processing of single-strand breaks (SSB) that are generated during BER have been causally associated with syndromes that present important neurological alterations and cognitive decline. In this review, the plasticity of BER during neurogenesis and the importance of an efficient BER for correct brain function will be specifically addressed paying particular attention to the brain region and neuron-selectivity in SSB repair-associated neurological syndromes and age-related neurodegenerative diseases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Encéfalo
/
Estrés Oxidativo
/
Reparación del ADN
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Enfermedades del Sistema Nervioso
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neural Plast
Asunto de la revista:
NEUROLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Italia