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Serum carnitine concentration is decreased in patients with Lyme borreliosis.
Kepka, Alina; Pancewicz, Slawomir A; Janas, Roman M; Swierzbinska, Renata.
Afiliación
  • Kepka A; Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland.
  • Pancewicz SA; Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Bialystok, Poland.
  • Janas RM; Department of Biochemistry, Radioimmunology and Experimental Medicine, The Children's Memorial Health Institute, Warsaw, Poland.
  • Swierzbinska R; Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Bialystok, Poland.
Postepy Hig Med Dosw (Online) ; 70: 180-5, 2016 Mar 04.
Article en En | MEDLINE | ID: mdl-26943315
BACKGROUND: Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons. AIM: To evaluate serum carnitine concentration in adult patients with various clinical types of LB. MATERIAL/METHODS: Groups: 1) patients with erythema migrans (EM, n=16), 2) neuroborreliosis (NB, n=10), 3) post-Lyme disease (PLD, n=22) and healthy controls (HC, n=32). Total (TC) and free (FC) carnitine were determined with the spectrophotometric method. RESULTS: TC levels (44.9±10.4, 28.0±8.4, 35.9±15.6 µmol/L) in the EM, NB and PLD patients were lower than in HC (54.0±11.4 µmol/L), p < 0.001. FC levels (32.7±7.7, 23.6±6.8, 26.3±11.2 µmol/L) in the EM, NB and PLD patients were lower than in HC (40.5±7.6 µmol/L), p < 0.001. AC levels (12.2±5.2, 4.4±2.6, 9.6±7.4 µmol/L) in the EM, NB and PLD patients were lower in the NB and PLD patients than in HC (13.5±8.40 µmol/L), p <0.001. AC/FC ratio was 0.31±0.14, 0.18±0.09, 0.39±0.33 in the EM, NB and PLD patients. CONCLUSIONS: LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Lyme / Carnitina Tipo de estudio: Observational_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Postepy Hig Med Dosw (Online) Asunto de la revista: ALERGIA E IMUNOLOGIA / MEDICINA / SAUDE PUBLICA Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Lyme / Carnitina Tipo de estudio: Observational_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Postepy Hig Med Dosw (Online) Asunto de la revista: ALERGIA E IMUNOLOGIA / MEDICINA / SAUDE PUBLICA Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Polonia