Ectopic bone formation with joint impingement after posterior lumbar fusion with rhBMP-2.
Orthop Traumatol Surg Res
; 102(2): 255-6, 2016 Apr.
Article
en En
| MEDLINE
| ID: mdl-26947733
ABSTRACT
Recombinant human bone morphogenetic protein-2 (rhBMP-2) was recently licensed for local administration during posterior lumbar fusion. In this indication, considerable uncertainty remains about the nature and mechanisms of the many adverse effects of rhBMP-2, such as ectopic bone formation. We report a case of ectopic bone formation with impingement on a facet joint and incapacitating low back pain after minimally invasive transforaminal L5-S1 interbody fusion with local application of rhBMP-2 (InductOs(®)). Revision surgery was eventually performed to alleviate the symptoms by removing the ectopic bone. Caution is in order regarding the use of rhBMP-2 during posterior lumbar fusion. Every effort should be made to minimise the risk of complications.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fusión Vertebral
/
Factor de Crecimiento Transformador beta
/
Osificación Heterotópica
/
Proteína Morfogenética Ósea 2
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Orthop Traumatol Surg Res
Año:
2016
Tipo del documento:
Article