[Psychopharmaceuticals for treatment of suicidal patients and for suicide prevention]. / Psychopharmaka zur Behandlung suizidaler Patienten und zur Suizidprävention.
Nervenarzt
; 87(5): 483-7, 2016 May.
Article
en De
| MEDLINE
| ID: mdl-26952239
ABSTRACT
Suicidality represents a frequent phenomenon in affective and psychotic disorders but the treatment of acute and chronic suicidality is still a controversial issue. Especially the efficacy of antidepressant and neuroleptic drugs for prevention of suicide continues to be debated. There is a lack of evidence due to limitations of methodological studies and ethical concerns are a major issue. Considering methodological problems in the conducted studies the often insufficiently valued differentiation between suicidal thoughts and actual suicidal behavior has to be emphasized. With the exception of lithium and clozapine suicide-preventing effects of antidepressants and neuroleptics could not yet be demonstrated. Regarding new antidepressant drugs, such as selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) even the possible new onset of suicidal thoughts and ideations as an adverse effect needs to be stressed. Considering the frequent occurrence of suicidality the currently available evidence is undoubtedly insufficient. The improvement of study concepts and especially a more differentiated consideration of the vague term "suicidality" seems to be essential. An underrepresentation of the evidence-based therapeutic options with lithium and clozapine in the treatment of suicidal patients needs to be avoided.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Psicotrópicos
/
Suicidio
/
Prevención del Suicidio
Aspecto:
Ethics
Límite:
Humans
Idioma:
De
Revista:
Nervenarzt
Año:
2016
Tipo del documento:
Article