Common antigens between hydatid cyst and cancers.
Adv Biomed Res
; 5: 9, 2016.
Article
en En
| MEDLINE
| ID: mdl-26962511
ABSTRACT
BACKGROUND:
Different research groups reported a negative correlation between cancers and parasitical infections. As an example, the prevalence of a hydatid cyst among patients with cancer was significantly lower than its prevalence among normal population. Tn antigens exist both in cancer and hydatid cyst. This common antigen may be involved in the effect of parasite on cancer growth. So in this work, common antigens between hydatid cyst and cancers have been investigated. MATERIALS ANDMETHODS:
Different hydatid cyst antigens including hydatid fluid, laminated and germinal layer antigens, and excretory secretory antigens of protoscolices were run in SDS PAGE and transferred to NCP paper. In western immunoblotting, those antigens were probed with sera of patients with different cancer and also sera of non-cancer patients. Also, cross reaction among excretory secretory products of cancer cells and antisera raised against different hydatid cyst antigen was investigated.RESULTS:
In western immunoblotting, antisera raised against laminated and germinal layers of hydatid cyst reacted with excretory secretory products of cancer cells. Also, a reaction was detected between hydatid cyst antigens and sera of patients with some cancers.CONCLUSION:
Results of this work emphasize existence of common antigens between hydatid cyst and cancers. More investigation about these common antigens is recommended.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Adv Biomed Res
Año:
2016
Tipo del documento:
Article
País de afiliación:
Irán