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CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.
Bartuzi, Paulina; Billadeau, Daniel D; Favier, Robert; Rong, Shunxing; Dekker, Daphne; Fedoseienko, Alina; Fieten, Hille; Wijers, Melinde; Levels, Johannes H; Huijkman, Nicolette; Kloosterhuis, Niels; van der Molen, Henk; Brufau, Gemma; Groen, Albert K; Elliott, Alison M; Kuivenhoven, Jan Albert; Plecko, Barbara; Grangl, Gernot; McGaughran, Julie; Horton, Jay D; Burstein, Ezra; Hofker, Marten H; van de Sluis, Bart.
Afiliación
  • Bartuzi P; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Billadeau DD; Department of Immunology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905, USA.
  • Favier R; Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905, USA.
  • Rong S; Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands.
  • Dekker D; Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
  • Fedoseienko A; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Fieten H; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Wijers M; Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands.
  • Levels JH; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Huijkman N; Department of Vascular and Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
  • Kloosterhuis N; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • van der Molen H; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Brufau G; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Groen AK; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Elliott AM; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Kuivenhoven JA; Department of Medical Genetics, University of British Columbia, 4500 Oak Street, Vancouver, British Columbia, Canada V6H 3N1.
  • Plecko B; Department of Pediatrics, Molecular Genetics Section, University of Groningen, University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
  • Grangl G; Department of Pediatrics and Adolescence Medicine, Division of Child Neurology, Medical University Graz, Auenbruggerplatz 2, A-8036 Graz, Austria.
  • McGaughran J; Division of Child Neurology, University Children's Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.
  • Horton JD; Department of Pediatrics and Adolescence Medicine, Division of Child Neurology, Medical University Graz, Auenbruggerplatz 2, A-8036 Graz, Austria.
  • Burstein E; Genetic Health Queensland at the Royal Brisbane and Women's Hospital, Herston, University of Queensland, Herston, Brisbane, Queensland 4029, Australia.
  • Hofker MH; School of Medicine, University of Queensland, Herston, Brisbane, Queensland 4029, Australia.
  • van de Sluis B; Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Nat Commun ; 7: 10961, 2016 Mar 11.
Article en En | MEDLINE | ID: mdl-26965651
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endosomas / Triglicéridos / Receptores de LDL / Proteínas / Proteínas Adaptadoras Transductoras de Señales / Hipercolesterolemia / LDL-Colesterol / Hígado / Proteínas de Microfilamentos Límite: Adolescent / Adult / Animals / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endosomas / Triglicéridos / Receptores de LDL / Proteínas / Proteínas Adaptadoras Transductoras de Señales / Hipercolesterolemia / LDL-Colesterol / Hígado / Proteínas de Microfilamentos Límite: Adolescent / Adult / Animals / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido