Insights into the substrate specificity of the MutT pyrophosphohydrolase using structural analogues of 8-oxo-2'-deoxyguanosine nucleotide.

Hamm, Michelle L; McFadden, Emily J; Ghio, Michael; Lindell, Maria A M; Gerien, Kenneth S; O'Handley, Suzanne F

Hamm, Michelle L; McFadden, Emily J; Ghio, Michael; Lindell, Maria A M; Gerien, Kenneth S; O'Handley, Suzanne F.

Afiliación

Hamm ML; Department of Chemistry, University of Richmond, Richmond, VA 23173, United States. Electronic address: mhamm@richmond.edu.
McFadden EJ; Department of Chemistry, University of Richmond, Richmond, VA 23173, United States.
Ghio M; Department of Chemistry, University of Richmond, Richmond, VA 23173, United States.
Lindell MA; Department of Chemistry, University of Richmond, Richmond, VA 23173, United States.
Gerien KS; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, NY 14623, United States.
O'Handley SF; School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, NY 14623, United States.

Bioorg Med Chem Lett ; 26(8): 2014-7, 2016 Apr 15.

Article en En | MEDLINE | ID: mdl-26965860

Asunto(s)

Desoxiguanosina/análogos & derivados; Proteínas de Escherichia coli/metabolismo; Pirofosfatasas/metabolismo; 8-Hidroxi-2'-Desoxicoguanosina; Desoxiguanosina/química; Desoxiguanosina/metabolismo; Modelos Moleculares; Conformación Molecular; Especificidad por Sustrato

Palabras clave

8-Oxo-2'-deoxyguanosine; DNA repair; MutT; Oxidized nucleotides

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirofosfatasas / Proteínas de Escherichia coli / Desoxiguanosina Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google