Nasal fluid secretory immunoglobulin A levels in children with allergic rhinitis.
Int J Pediatr Otorhinolaryngol
; 83: 41-6, 2016 Apr.
Article
en En
| MEDLINE
| ID: mdl-26968051
ABSTRACT
OBJECTIVES:
There is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either being treated for their allergic rhinitis (AR) with intranasal mometasone furoate or were not receiving treatment.METHODS:
The study population contained 55 children with persistent AR. Group I included 27 newly diagnosed AR patients not taking any medication and group II included 28 patients treated with intranasal steroids for at least 6 months. 27 healthy control subjects were also enrolled in the study. Total symptom scores (TSS) were calculated for each patient. Nasal secretions were obtained using a new modified polyurethane sponge absorption method, and samples were analysed by ELISA.RESULTS:
The median value for nasal fluid SIgA level in each group was 127.2µg/ml (interquartile range; 67.3-149.6) in group I, 133.9µg/ml (102.1-177.8) in group II and 299.8µg/ml (144.5-414.0) in the control group. Groups I and II both had statistically significant reductions in nasal fluid SIgA levels compared to the control group (p<0.001). However, there was no statistically significant difference between groups I and II (p=0.35). A statistically significant and negative correlation also existed between TSS and nasal fluid SIgA levels in both groups I and II (p=0.006, rho=-0.512 and p=0.01, rho=-0.481, respectively).CONCLUSIONS:
SIgA levels in the nasal fluid are significantly reduced in children with AR independent of treatment and are negatively correlated with the TSS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina A Secretora
/
Líquido del Lavado Nasal
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Antialérgicos
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Rinitis Alérgica
/
Furoato de Mometasona
Tipo de estudio:
Observational_studies
Límite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Int J Pediatr Otorhinolaryngol
Año:
2016
Tipo del documento:
Article