Efficacy of dexamethasone intravitreal implant for the treatment of persistent diffuse diabetic macular edema.
Int Ophthalmol
; 37(1): 1-6, 2017 Feb.
Article
en En
| MEDLINE
| ID: mdl-26968412
ABSTRACT
To investigate the efficiency and safety of a single injection of intravitreal dexamethasone implant in eyes with persistent diffuse diabetic macular edema (DME). In this retrospective study, 25 eyes of 20 patients, who underwent a single injection of intravitreal dexamethasone implant for the treatment of persistent diffuse DME, were reviewed. Main outcome measures included the changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT) from baseline at scheduled visits following injection. The mean BCVA showed improvement from baseline (0.97 ± 0.26 logMAR) at every visit; the difference was significant at day 7 (0.85 ± 0.3 logMAR, p = 0.003), month 1 (0.77 ± 0.32 logMAR, p < 0.001), month 3 (0.77 ± 0.34 logMAR, p = 0.001), and month 4 (0.85 ± 0.31 logMAR, p = 0.014). The mean CMT was significantly lower than baseline (616 ± 132 µm) at day 1 (518 ± 144 µm), day 7 (414 ± 134 µm), month 1 (306 ± 95 µm), month 3 (339 ± 88 µm), month 4 (420 ± 116 µm), and month 6 (494 ± 128 µm) following the injection (p < 0.001, for all). Thirteen eyes on the 4-month follow-up and ten eyes on the 6-month follow-up experienced recurrence of macular edema requiring retreatment. No serious ocular and systemic adverse events were observed. In patients with persistent DME, switching to intravitreal dexamethasone implant injection provides functional and anatomical improvement, and might be an effective therapeutic option for long-standing diffuse DME.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dexametasona
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Edema Macular
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Retinopatía Diabética
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Implantes de Medicamentos
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Glucocorticoides
Tipo de estudio:
Observational_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Int Ophthalmol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Turquía