Advances in development of fluorescent probes for detecting amyloid-ß aggregates.
Acta Pharmacol Sin
; 37(6): 719-30, 2016 Jun.
Article
en En
| MEDLINE
| ID: mdl-26997567
ABSTRACT
With accumulating evidence suggesting that amyloid-ß (Aß) deposition is a good diagnostic biomarker for Alzheimer's disease (AD), the discovery of active Aß probes has become an active area of research. Among the existing imaging methods, optical imaging targeting Aß aggregates (fibrils or oligomers), especially using near-infrared (NIR) fluorescent probes, is increasingly recognized as a promising approach for the early diagnosis of AD due to its real time detection, low cost, lack of radioactive exposure and high-resolution. In the past decade, a variety of fluorescent probes have been developed and tested for efficiency in vitro, and several probes have shown efficacy in AD transgenic mice. This review classifies these representative probes based on their chemical structures and functional modes (dominant solvent-dependent mode and a novel solvent-independent mode). Moreover, the pharmaceutical characteristics of these representative probes are summarized and discussed. This review provides important perspectives for the future development of novel NIR Aß diagnostic probes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos beta-Amiloides
/
Enfermedad de Alzheimer
/
Imagen Óptica
/
Colorantes Fluorescentes
Tipo de estudio:
Screening_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Pharmacol Sin
Asunto de la revista:
FARMACOLOGIA
Año:
2016
Tipo del documento:
Article
País de afiliación:
China