Biocompatible hybrid silica nanobiocomposites for the efficient delivery of anti-staphylococcal drugs.
Int J Pharm
; 510(2): 532-42, 2016 Aug 30.
Article
en En
| MEDLINE
| ID: mdl-27032567
ABSTRACT
This work reports the non-surfactant templated synthesis and characterization of a new tyrosine-silica/antibiotics (TyR-SiO2/ATBs) nanocomposite, as well as both in vitro and in vivo cytotoxicity and antimicrobial activity against the microbial pathogen Staphylococcus aureus. The in vitro microbiological tests proved that the obtained nanobiostructure significantly enhance the antimicrobial activity of three commonly used antibiotics against S. aureus (i.e. erythromycin (ERI), gentamicin (GEN), and cloxacillin (CLO)) as revealed by the increased diameters of the growth inhibition zones and the decreased minimal inhibitory concentration values, as well as by the inhibitory effect of sub-lethal antibiotic concentrations on the ability of the respective pathogenic strains to adhere and colonize different substrata. These results, correlated with the lack of toxicity against mesenchymal stem cells along with an appropriate in vivo biodistribution highlight the promising therapeutic potential of this carrier that allows a decrease of the required active doses while significantly lessening the harmful side effects of the medication on the host organism.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Estafilocócicas
/
Staphylococcus aureus
/
Materiales Biocompatibles
/
Dióxido de Silicio
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Antibacterianos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Int J Pharm
Año:
2016
Tipo del documento:
Article
País de afiliación:
Rumanía