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Enantioselective Synthesis of Silacyclopentanes.
Igawa, Kazunobu; Yoshihiro, Daisuke; Abe, Yusuke; Tomooka, Katsuhiko.
Afiliación
  • Igawa K; Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka, 816-8580, Japan. kigawa@cm.kyushu-u.ac.jp.
  • Yoshihiro D; Department of Molecular and Material Sciences, Kyushu University, Japan.
  • Abe Y; Department of Molecular and Material Sciences, Kyushu University, Japan.
  • Tomooka K; Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka, 816-8580, Japan. ktomooka@cm.kyushu-u.ac.jp.
Angew Chem Int Ed Engl ; 55(19): 5814-8, 2016 05 04.
Article en En | MEDLINE | ID: mdl-27037672
ABSTRACT
A variety of functionalized silacyclopentanes were synthesized by highly enantioselective ß-eliminations of silacyclopentene oxides followed by stereospecific transformations. The reaction mechanism of the ß-elimination was elucidated by DFT calculations. An in vitro biological assay with an oxy-functionalized silacyclopentane showed substantial binding to a serotonin receptor protein.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2016 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Angew Chem Int Ed Engl Año: 2016 Tipo del documento: Article País de afiliación: Japón