Asymmetric Synthesis of Axinellamines A and B.

Ma, Zhiqiang; Wang, Xiao; Ma, Yuyong; Chen, Chuo

Ma, Zhiqiang; Wang, Xiao; Ma, Yuyong; Chen, Chuo.

Afiliación

Ma Z; Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Wang X; Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.
Ma Y; Department of Chemistry and Biochemistry, The University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Chen C; Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA.

Angew Chem Int Ed Engl ; 55(15): 4763-6, 2016 Apr 04.

Article en En | MEDLINE | ID: mdl-27037993

ABSTRACT

ABSTRACT

AxinellaminesâA and B are broad-spectrum antibacterial pyrrole-imidazole alkaloids that have a complex polycyclic skeleton. A new asymmetric synthesis of these marine sponge metabolites is described herein, featuring an oxidative rearrangement and an anchimeric chlorination reaction.

Asunto(s)

Imidazoles/síntesis química; Pirroles/síntesis química; Isomerismo

Palabras clave

alkaloids; anchimeric assistance; axinellamines; natural products; total synthesis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirroles / Imidazoles Idioma: En Revista: Angew Chem Int Ed Engl Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos

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