A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3.

Makino, Yusuke; Hamamura, Kazunori; Takei, Yoshifumi; Bhuiyan, Robiul Hasan; Ohkawa, Yuki; Ohmi, Yuhsuke; Nakashima, Hideyuki; Furukawa, Keiko; Furukawa, Koichi

Makino, Yusuke; Hamamura, Kazunori; Takei, Yoshifumi; Bhuiyan, Robiul Hasan; Ohkawa, Yuki; Ohmi, Yuhsuke; Nakashima, Hideyuki; Furukawa, Keiko; Furukawa, Koichi.

Afiliación

Makino Y; Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan.
Hamamura K; Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan.
Takei Y; Department of Molecular Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan.
Bhuiyan RH; Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan.
Ohkawa Y; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan.
Ohmi Y; Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan.
Nakashima H; Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan.
Furukawa K; Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan.
Furukawa K; Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-0065, Japan; Department of Biomedical Sciences, Chubu University College of Life and Health Sciences, 1200 Matsumoto, Kasugai 487-8501, Japan. Electronic address: koichi@med.nagoya-u.ac.jp

Biochim Biophys Acta ; 1860(8): 1753-63, 2016 Aug.

Article en En | MEDLINE | ID: mdl-27068854

Asunto(s)

Proteína Sustrato Asociada a CrK; Gangliósidos; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Melanoma; Proteínas de Neoplasias; Paxillin; ARN Interferente Pequeño; Animales; Línea Celular Tumoral; Proteína Sustrato Asociada a CrK/antagonistas & inhibidores; Proteína Sustrato Asociada a CrK/biosíntesis; Proteína Sustrato Asociada a CrK/genética; Gangliósidos/biosíntesis; Gangliósidos/genética; Humanos; Melanoma/tratamiento farmacológico; Melanoma/genética; Melanoma/metabolismo; Melanoma/patología; Ratones; Ratones Desnudos; Proteínas de Neoplasias/antagonistas & inhibidores; Proteínas de Neoplasias/biosíntesis; Proteínas de Neoplasias/genética; Paxillin/antagonistas & inhibidores; Paxillin/biosíntesis; Paxillin/genética; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/farmacología; Transducción de Señal; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Atelocollagen; GD3; Melanoma; Paxillin; Small interfering RNA; p130Cas

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / ARN Interferente Pequeño / Proteína Sustrato Asociada a CrK / Paxillin / Gangliósidos / Melanoma / Proteínas de Neoplasias Límite: Animals / Humans Idioma: En Revista: Biochim Biophys Acta Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos

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