Effects of inhibiting connexin43 on expression of fibroblast growth factor in prolactinomas in rats.

Wang, Haitao; Gao, Bo; Zhang, Yaju; Xu, Hua

Wang, Haitao; Gao, Bo; Zhang, Yaju; Xu, Hua.

Afiliación

Wang H; a Department of Neurosurgery , The Affiliated Hospital of Jining Medical University , Jining , China.
Gao B; a Department of Neurosurgery , The Affiliated Hospital of Jining Medical University , Jining , China.
Zhang Y; b Department of Rehabilitation Medicine , The Affiliated Hospital of Jining Medical University , Jining , China.
Xu H; a Department of Neurosurgery , The Affiliated Hospital of Jining Medical University , Jining , China.

Neurol Res ; 38(5): 456-60, 2016 May.

Article en En | MEDLINE | ID: mdl-27078698

ABSTRACT

ABSTRACT

OBJECTIVE:

The aim of this study was to investigate the effect of connexin43(Cx43) on basic fibroblast growth factor (bFGF) expression by inhibiting Cx43 expression in prolactinomas in rats.

METHODS:

An experimental rat model of prolactinoma induced by estradiol (E2) treatment was used. Gap junction inhibitor was applied in through the arachnoid space by injection of carbenoxolone (CBX). Cx43 and bFGF expression was examined by both western blotting, respectively.

RESULTS:

Pituitaries treated with E2 were hypertrophic, but this was reduced by CBX treatment. Estradiol induced Cx43 and bFGF expression, which decreased following CBX treatment.

CONCLUSIONS:

Altered Cx43 expression modulates bFGF expression, which correlates with prolactinoma development.

Asunto(s)

Conexina 43/metabolismo; Factores de Crecimiento de Fibroblastos/metabolismo; Neoplasias Hipofisarias/metabolismo; Prolactinoma/metabolismo; Análisis de Varianza; Animales; Carbenoxolona/uso terapéutico; Modelos Animales de Enfermedad; Estradiol/toxicidad; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Tamaño de los Órganos/efectos de los fármacos; Hipófisis/efectos de los fármacos; Hipófisis/patología; Neoplasias Hipofisarias/inducido químicamente; Neoplasias Hipofisarias/tratamiento farmacológico; Prolactinoma/inducido químicamente; Prolactinoma/tratamiento farmacológico; Ratas

Palabras clave

Connexin43; Fibroblast growth factor; Gap junction inhibitor; Prolactinoma

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Hipofisarias / Prolactinoma / Conexina 43 / Factores de Crecimiento de Fibroblastos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurol Res Año: 2016 Tipo del documento: Article País de afiliación: China

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