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PPMP, a novel tubulin-depolymerizing agent against esophageal cancer in patient-derived tumor xenografts.
Sheng, Yuqiao; Liu, Kangdong; Wu, Qiong; Oi, Naomi; Chen, Hanyong; Reddy, Kanamata; Jiang, Yanan; Yao, Ke; Li, Haitao; Li, Wei; Zhang, Yi; Saleem, Mohammad; Ma, Wei-Ya; Bode, Ann M; Dong, Ziming; Dong, Zigang.
Afiliación
  • Sheng Y; Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China.
  • Liu K; The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
  • Wu Q; The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
  • Oi N; Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China.
  • Chen H; The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
  • Reddy K; China-US (Henan) Hormel Cancer Institute, ZhengZhou, Henan, China.
  • Jiang Y; Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China.
  • Yao K; China-US (Henan) Hormel Cancer Institute, ZhengZhou, Henan, China.
  • Li H; The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
  • Li W; The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
  • Zhang Y; The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
  • Saleem M; Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China.
  • Ma WY; The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
  • Bode AM; The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
  • Dong Z; The Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
  • Dong Z; Basic Medical College, Zhengzhou University, Zhengzhou, Henan, China.
Oncotarget ; 7(21): 30977-89, 2016 May 24.
Article en En | MEDLINE | ID: mdl-27129160
ABSTRACT
Esophageal cancer is one of the least studied and deadliest cancers worldwide with a poor prognosis due to limited options for treatment. Chemotherapy agents such as the microtubule-targeting compounds are the mainstay of palliation for advanced esophageal cancer treatment. However, the toxicity and side effects of tubulin-binding agents (TBAs) have promoted the development of novel, more potent but less toxic TBAs. Herein, we identified 2-[4-(3,4-dimethoxyphenyl)-3-methyl-1H-pyrazol-5-yl]-5-[(2-methylprop-2-en-1-yl)oxy] phenol (PPMP) as a novel TBA for esophageal cancer treatment. PPMP markedly inhibited tubulin polymerization, and decreased viability and anchorage-independent growth of esophageal cancer cell lines, effects that were accompanied by G2/M arrest and apoptosis. Importantly, we produced patient-derived esophageal cancer xenografts to evaluate the therapeutic effect of PPMP in a setting that best mimics the clinical context in patients with esophageal cancer. Overall, we identified PPMP as a novel microtubule-destabilizing compound and as a new therapeutic agent against esophageal carcinoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Moduladores de Tubulina / Meperidina Límite: Animals / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article País de afiliación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Moduladores de Tubulina / Meperidina Límite: Animals / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article País de afiliación: China