Can procalcitonin be a diagnostic marker for catheter-related blood stream infection in children?
J Pediatr (Rio J)
; 92(4): 414-20, 2016.
Article
en En
| MEDLINE
| ID: mdl-27131015
ABSTRACT
OBJECTIVE:
The potential role of procalcitonin (PCT) in the diagnosis of catheter-related bloodstream infection (CRBSIs) is still unclear and requires further research. The diagnostic value of serum PCT for the diagnosis of CRBSI in children is evaluated here.METHOD:
This study was conducted between October 2013 and November 2014, and included patients with suspected CRBSI from 1 month to 18 years of age who were febrile, with no focus of infection, and had a central venous catheter. Levels of PCT and other serum markers were measured, and their utility as CRBSI markers was assessed. Additionally, the clinical performance of a new, automated, rapid, and quantitative assay for the detection of PCT was tested.RESULTS:
Among the 49 patients, 24 were diagnosed with CRBSI. The PCT-Kryptor and PCT-RTA values were significantly higher in proven CRBSI compared to those in unproven CRBSI (p=0.03 and p=0.03, respectively). There were no differences in white blood cell count and C-reactive protein (CRP) levels between proven CRBSI and unproven CRBSI. Among the 24 patients with CRBSI, CRP was significantly higher among those with Gram-negative bacterial infection than in those with Gram-positive bacterial infections. PCT-Kryptor was also significantly higher among patients with Gram-negative bacterial infection than in those with Gram-positive bacterial infections (p=0.01 and p=0.02, respectively).CONCLUSIONS:
The authors suggest that PCT could be a helpful rapid diagnostic marker in children with suspected CRBSIs.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Calcitonina
/
Bacteriemia
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Infecciones Relacionadas con Catéteres
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Adolescent
/
Child
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Child, preschool
/
Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Revista:
J Pediatr (Rio J)
Año:
2016
Tipo del documento:
Article