The effect of locoregional therapies in patients with advanced hepatocellular carcinoma treated with sorafenib.
HPB (Oxford)
; 18(5): 411-8, 2016 05.
Article
en En
| MEDLINE
| ID: mdl-27154804
ABSTRACT
BACKGROUND & AIMS:
It is unknown whether the addition of locoregional therapies (LRTx) to sorafenib improves prognosis over sorafenib alone in patients with advanced hepatocellular carcinoma (HCC). The aim of this study was to assess the effect of LRTx in this population.METHODS:
A retrospective analysis was performed of patients with advanced HCC as defined by extrahepatic metastasis, lymphadenopathy >2 cm, or gross vascular invasion. Sorafenib therapy was required for inclusion. Survival of patients who received LRTx after progression to advanced stage was compared to those who did not receive LRTx.RESULTS:
Using an intention to treat analysis of 312 eligible patients, a propensity weighted proportional hazards model demonstrated LRTx as a predictor of survival (HR = 0.505, 95% CI 0.407-0.628; P < 0.001). The greatest benefit was seen in patients with the largest tumor burden (HR = 0.305, 95% CI 0.236-0.393; P < 0.01). Median survival in the sorafenib arm was 143 days (95% CI 118-161) vs. 247 days (95% CI 220-289) in the sorafenib plus LRTx arm (P < 0.001).CONCLUSIONS:
These results demonstrate a survival benefit with the addition of LRTx to sorafenib for patients with advanced HCC. These findings should prompt a prospective clinical trial to further assess the role of LRTx in patients with advanced HCC.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Fenilurea
/
Quimioembolización Terapéutica
/
Niacinamida
/
Carcinoma Hepatocelular
/
Técnicas de Ablación
/
Quimioradioterapia Adyuvante
/
Neoplasias Hepáticas
/
Antineoplásicos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
HPB (Oxford)
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2016
Tipo del documento:
Article