Concurrent nuclear ERG and MYC protein overexpression defines a subset of locally advanced prostate cancer: Potential opportunities for synergistic targeted therapeutics.

Udager, Aaron M; DeMarzo, Angelo M; Shi, Yang; Hicks, Jessica L; Cao, Xuhong; Siddiqui, Javed; Jiang, Hui; Chinnaiyan, Arul M; Mehra, Rohit

Udager, Aaron M; DeMarzo, Angelo M; Shi, Yang; Hicks, Jessica L; Cao, Xuhong; Siddiqui, Javed; Jiang, Hui; Chinnaiyan, Arul M; Mehra, Rohit.

Afiliación

Udager AM; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan.
DeMarzo AM; Department of Pathology, The Sidney Kimmel Comprehensive Cancer Center and The James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
Shi Y; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan.
Hicks JL; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
Cao X; Department of Pathology, The Sidney Kimmel Comprehensive Cancer Center and The James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland.
Siddiqui J; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
Jiang H; Michigan Center for Translational Pathology, Ann Arbor, Michigan.
Chinnaiyan AM; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan.
Mehra R; Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan.

Prostate ; 76(9): 845-53, 2016 06.

Article en En | MEDLINE | ID: mdl-27159573

Asunto(s)

Regulación Neoplásica de la Expresión Génica; Neoplasias de la Próstata/genética; Proteínas Proto-Oncogénicas c-myc/genética; Humanos; Inmunohistoquímica; Masculino; Recurrencia Local de Neoplasia/genética; Recurrencia Local de Neoplasia/metabolismo; Recurrencia Local de Neoplasia/patología; Fusión de Oncogenes; Neoplasias de la Próstata/metabolismo; Neoplasias de la Próstata/patología; Proteínas Proto-Oncogénicas c-myc/metabolismo; Análisis de Matrices Tisulares; Regulador Transcripcional ERG/genética; Regulador Transcripcional ERG/metabolismo

Palabras clave

BET bromodomain; ERG; MYC; immunohistochemistry (IHC); prostate cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Regulación Neoplásica de la Expresión Génica / Proteínas Proto-Oncogénicas c-myc Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Prostate Año: 2016 Tipo del documento: Article

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