Differential effects of naloxone on rewarding electrical stimulation of the central nucleus of the amygdala and parabrachial complex in a place preference study.
Brain Res Bull
; 124: 182-9, 2016 06.
Article
en En
| MEDLINE
| ID: mdl-27173444
ABSTRACT
The central nucleus of the amygdala (CeA) is considered to be involved in different affective, sensory, regulatory, and acquisition processes. This study analyzed whether electrical stimulation of the PB-CeA system induces preferences in a concurrent place preference (cPP) task, as observed after stimulation of the parabrachial-insular cortex (PB-IC) axis. It also examined whether the rewarding effects are naloxone-dependent. The results show that electrical stimulation of the CeA and external lateral parabrachial subnucleus (LPBe) induces consistent preference behaviors in a cPP task. However, subcutaneous administration of an opiate antagonist (naloxone; 4mg/ml/kg) blocked the rewarding effect of the parabrachial stimulation but not that of the amygdala stimulation. These results are interpreted in the context of multiple brain reward systems that appear to differ both anatomically and neurochemically, notably with respect to the opiate system.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recompensa
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Estimulación Eléctrica
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Núcleos Parabraquiales
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Núcleo Amigdalino Central
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Naloxona
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Antagonistas de Narcóticos
Aspecto:
Patient_preference
Límite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Año:
2016
Tipo del documento:
Article