Enhancement of the CXCL12/CXCR4 axis due to acquisition of gemcitabine resistance in pancreatic cancer: effect of CXCR4 antagonists.

Morimoto, Mamoru; Matsuo, Yoichi; Koide, Shuji; Tsuboi, Ken; Shamoto, Tomoya; Sato, Takafumi; Saito, Kenta; Takahashi, Hiroki; Takeyama, Hiromitsu

Morimoto, Mamoru; Matsuo, Yoichi; Koide, Shuji; Tsuboi, Ken; Shamoto, Tomoya; Sato, Takafumi; Saito, Kenta; Takahashi, Hiroki; Takeyama, Hiromitsu.

Afiliación

Morimoto M; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan.
Matsuo Y; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan. matsuo@med.nagoya-cu.ac.jp.
Koide S; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan.
Tsuboi K; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan.
Shamoto T; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan.
Sato T; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan.
Saito K; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan.
Takahashi H; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan.
Takeyama H; Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho-cho, Mizuhoku, Nagoya, 467-8601, Japan.

BMC Cancer ; 16: 305, 2016 05 12.

Article en En | MEDLINE | ID: mdl-27175473

Asunto(s)

Quimiocina CXCL12/metabolismo; Desoxicitidina/análogos & derivados; Compuestos Heterocíclicos con 1 Anillo/farmacología; Neoplasias Pancreáticas/metabolismo; Receptores CXCR4/antagonistas & inhibidores; Receptores CXCR4/metabolismo; Aminoquinolinas; Animales; Antimetabolitos Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Bencimidazoles; Butilaminas; Proliferación Celular/efectos de los fármacos; Desoxicitidina/farmacología; Femenino; Fibroblastos/efectos de los fármacos; Fibroblastos/metabolismo; Fibroblastos/patología; Humanos; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Neoplasias Pancreáticas/tratamiento farmacológico; Neoplasias Pancreáticas/patología; Células del Estroma/efectos de los fármacos; Células del Estroma/metabolismo; Células del Estroma/patología; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto; Gemcitabina

Palabras clave

CXCL12; CXCR4; CXCR4 antagonist; Gemcitabine resistant; Pancreatic cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Receptores CXCR4 / Desoxicitidina / Quimiocina CXCL12 / Compuestos Heterocíclicos con 1 Anillo Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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