Trastuzumab, but Not Pertuzumab, Dysregulates HER2 Signaling to Mediate Inhibition of Autophagy and Increase in Reactive Oxygen Species Production in Human Cardiomyocytes.

Mohan, Nishant; Shen, Yi; Endo, Yukinori; ElZarrad, M Khair; Wu, Wen Jin

Mohan, Nishant; Shen, Yi; Endo, Yukinori; ElZarrad, M Khair; Wu, Wen Jin.

Afiliación

Mohan N; Division of Biotechnology Research and Review I, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland.
Shen Y; Division of Biotechnology Research and Review I, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland.
Endo Y; Division of Biotechnology Research and Review I, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland.
ElZarrad MK; Division of Biotechnology Research and Review I, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland.
Wu WJ; Division of Biotechnology Research and Review I, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. wen.wu@fda.hhs.gov.

Mol Cancer Ther ; 15(6): 1321-31, 2016 06.

Article en En | MEDLINE | ID: mdl-27197303

Asunto(s)

Anticuerpos Monoclonales Humanizados/efectos adversos; Receptores ErbB/metabolismo; Miocitos Cardíacos/efectos de los fármacos; Receptor ErbB-2/metabolismo; Trastuzumab/efectos adversos; Animales; Anticuerpos Monoclonales Humanizados/farmacología; Autofagia/efectos de los fármacos; Células Cultivadas; Regulación hacia Abajo; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Sistema de Señalización de MAP Quinasas/efectos de los fármacos; Ratones; Ratones Endogámicos C57BL; Miocitos Cardíacos/citología; Miocitos Cardíacos/metabolismo; Fosforilación/efectos de los fármacos; Especies Reactivas de Oxígeno/metabolismo; Trastuzumab/farmacología

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptor ErbB-2 / Miocitos Cardíacos / Anticuerpos Monoclonales Humanizados / Receptores ErbB / Trastuzumab Límite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos

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