Effects of oral terbutaline in chronic airflow limitation.
Chest
; 95(6): 1248-52, 1989 Jun.
Article
en En
| MEDLINE
| ID: mdl-2721259
ABSTRACT
A randomized, double-blind, crossover study was conducted to assess the efficacy of five weeks' treatment with terbutaline, 15 mg daily, compared with placebo in 17 evaluable patients with moderate to severe chronic airflow limitation (CAL) with a minor reversible component. A significant improvement after terbutaline treatment compared with placebo was observed in subjective assessments of breathlessness after two of the activities of daily living, and in daily peak flow measurements recorded in patient diaries. At the clinical assessment after five weeks' terbutaline therapy, 12 of 17 patients had improved pulmonary symptom scores compared with placebo, and a slight increase in FEV1 was observed relative to placebo (0.09 L, p less than 0.05). Thus, five weeks' treatment with oral terbutaline in patients with CAL resulted in significant improvements in several subjective assessments, despite a lack of effect on the majority of the objective variables.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Terbutalina
/
Enfermedades Pulmonares Obstructivas
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Chest
Año:
1989
Tipo del documento:
Article
País de afiliación:
Dinamarca