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[Calcium channel modulators as antidotes in fatal imipramine poisoning]. / Effets antidotes de certains modulateurs des canaux calciques dans l'intoxication létale à l'imipramine.
Sitbon, M; Trouvé, R; Latour, C; Nahas, G G.
Afiliación
  • Sitbon M; Laboratoire de Pharmacologie et Toxicologie cellulaires, INSERM, Hôpital Fernand Widal, Paris.
Encephale ; 15(1): 43-7, 1989.
Article en Fr | MEDLINE | ID: mdl-2721438
Calcium entry modulators were tested as antidotes to imipramine lethal toxicity. 42 rats were administered intraperitoneally 85 mg/kg of imipramine. In 6 control rats, hypotension and bradycardia were observed. Survival time was 15' +/- 5'. Survival time of rats treated with intraarterial nitrendipine was 21' +/- 11'. Survival time of 5 out of 6 rats treated by intraarterial verapamil or diltiazem was respectively 19'00" +/- 14'30" and 40'30" +/- 32'00". 5 out of 6 rats treated by intraarterial nimodipine, as well as all of the rats treated by flunarizine or nicardipine survived and were alive and active 48 hours later. Intoxication with imipramine may induce life threatening complications for which there are no specific medication. Nicardipine might be considered in the treatment of acute poisoning by imipramine and related tricyclic compounds.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Calcio / Hipotensión / Imipramina Límite: Animals Idioma: Fr Revista: Encephale Año: 1989 Tipo del documento: Article Pais de publicación: Francia
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bloqueadores de los Canales de Calcio / Hipotensión / Imipramina Límite: Animals Idioma: Fr Revista: Encephale Año: 1989 Tipo del documento: Article Pais de publicación: Francia