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In Vivo Bone-Targeting of Bis(phosphonate)-Conjugated Double Helical RNA Monitored by Positron Emission Tomography.
Jadhav, Satish; Käkelä, Meeri; Bourgery, Matthieu; Rimpilä, Kiira; Liljenbäck, Heidi; Siitonen, Riikka; Mäkilä, Jussi; Laitala-Leinonen, Tiina; Poijärvi-Virta, Päivi; Lönnberg, Harri; Roivainen, Anne; Virta, Pasi.
Afiliación
  • Jadhav S; Department of Chemistry, University of Turku , FI-20014 Turku, Finland.
  • Käkelä M; Turku PET Centre, University of Turku , FI-20521 Turku, Finland.
  • Bourgery M; Turku PET Centre, Turku University Hospital , FI-20521 Turku, Finland.
  • Rimpilä K; Department of Cell Biology and Anatomy, University of Turku , FI-20520 Turku, Finland.
  • Liljenbäck H; Department of Chemistry, University of Turku , FI-20014 Turku, Finland.
  • Siitonen R; Turku PET Centre, University of Turku , FI-20521 Turku, Finland.
  • Mäkilä J; Turku PET Centre, Turku University Hospital , FI-20521 Turku, Finland.
  • Laitala-Leinonen T; Turku Center for Disease Modeling, University of Turku , FI-20520 Turku, Finland.
  • Poijärvi-Virta P; Turku PET Centre, University of Turku , FI-20521 Turku, Finland.
  • Lönnberg H; Turku PET Centre, Turku University Hospital , FI-20521 Turku, Finland.
  • Roivainen A; Turku PET Centre, University of Turku , FI-20521 Turku, Finland.
  • Virta P; Turku PET Centre, Turku University Hospital , FI-20521 Turku, Finland.
Mol Pharm ; 13(7): 2588-95, 2016 07 05.
Article en En | MEDLINE | ID: mdl-27218688
A bis(phosphonate) conjugate of 2'-O-methyl oligoribonucleotide (microRNA-21) was synthesized and used as a bone-targeting carrier in the systemic delivery of a (68)Ga-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-chelated 2'-O-methyl oligoribonucleotide (anti-microRNA-21). The whole-body biodistribution of the double helical RNA was monitored by positron emission tomography (PET), which verified the expected bis(phosphonate)-induced bone accumulation in healthy rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN / Tomografía de Emisión de Positrones / Radioisótopos de Galio Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN / Tomografía de Emisión de Positrones / Radioisótopos de Galio Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos