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Endoperoxy and hydroperoxy cadinane-type sesquiterpenoids from an Okinawan soft coral, Sinularia sp.
Roy, Prodip K; Ashimine, Runa; Miyazato, Haruna; Taira, Junsei; Ueda, Katsuhiro.
Afiliación
  • Roy PK; Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-Cho, Okinawa, 903-2013, Japan. prodipkroy@gmail.com.
  • Ashimine R; Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-Cho, Okinawa, 903-2013, Japan.
  • Miyazato H; Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-Shi, Okinawa, 905-2192, Japan.
  • Taira J; Department of Bioresources Engineering, Okinawa National College of Technology, 905 Henoko, Nago-Shi, Okinawa, 905-2192, Japan.
  • Ueda K; Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, 1 Senbaru, Nishihara-Cho, Okinawa, 903-2013, Japan. kueda@sci.u-ryukyu.ac.jp.
Arch Pharm Res ; 39(6): 778-84, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27230778
ABSTRACT
Three cadinane-type sesquiterpenoids, endoperoxide (1) and hydroperoxides (2, 3) together with three known sesquiterpenoids (4-6) were isolated from an Okinawan soft coral, Sinularia species. Structures of these isolates were elucidated by spectroscopic analyses (NMR, IR and MS) and molecular modeling. In addition, the isolates 1-3 as new compounds were examined for biological activities, resulting that they have antibacterial activity and weak cytotoxicity against HCT116 cells as well as anti-inflammatory effect on LPS/IFN-γ-stimulated RAW 264.7 macrophage cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Antozoos / Descubrimiento de Drogas / Antiinflamatorios / Antibacterianos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Arch Pharm Res Año: 2016 Tipo del documento: Article País de afiliación: Japón
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Antozoos / Descubrimiento de Drogas / Antiinflamatorios / Antibacterianos / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Arch Pharm Res Año: 2016 Tipo del documento: Article País de afiliación: Japón