Tight junctions as regulators of tissue remodelling.
Curr Opin Cell Biol
; 42: 94-101, 2016 10.
Article
en En
| MEDLINE
| ID: mdl-27236618
ABSTRACT
Formation of tissue barriers by epithelial and endothelial cells requires neighbouring cells to interact via intercellular junctions, which includes tight junctions. Tight junctions form a semipermeable paracellular diffusion barrier and act as signalling hubs that guide cell behaviour and differentiation. Components of tight junctions are also expressed in cell types not forming tight junctions, such as cardiomyocytes, where they associate with facia adherens and/or gap junctions. This review will focus on tight junction proteins and their importance in tissue homeostasis and remodelling with a particular emphasis on what we have learned from animal models and human diseases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Especificidad de Órganos
/
Uniones Estrechas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Año:
2016
Tipo del documento:
Article