Quantitative structure-activity relationship study on some dihydropteridine reductase inhibitors.
J Enzyme Inhib
; 2(4): 231-7, 1989.
Article
en En
| MEDLINE
| ID: mdl-2723771
ABSTRACT
The dihydropteridine reductase (DHPR) inhibitory potencies of some 4-phenyltetrahydropyridines, 4-phenylpiperidines, and 4-phenylpyridines, are analyzed in relation to their physico-chemical and molecular properties. They are found to have significant correlation with Hammett constant sigma and the van der Waals volume Vw. The correlation is linear with sigma and parabolic with Vw. Hence, it is argued that DHPR inhibition involves dispersion interaction and is enhanced by electron donation from the substituents but hindered by steric effects produced by large substituents. It is also found that these electronic and steric effects are significant only when they are produced by substituents being at specific position in the molecules.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Piridinas
/
Dihidropteridina Reductasa
/
NADH NADPH Oxidorreductasas
Idioma:
En
Revista:
J Enzyme Inhib
Asunto de la revista:
BIOQUIMICA
Año:
1989
Tipo del documento:
Article
País de afiliación:
India