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Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.
Tewhey, Ryan; Kotliar, Dylan; Park, Daniel S; Liu, Brandon; Winnicki, Sarah; Reilly, Steven K; Andersen, Kristian G; Mikkelsen, Tarjei S; Lander, Eric S; Schaffner, Stephen F; Sabeti, Pardis C.
Afiliación
  • Tewhey R; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address: rtewhey@broadinstitute.org.
  • Kotliar D; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Park DS; Broad Institute, Cambridge, MA 02142, USA.
  • Liu B; Broad Institute, Cambridge, MA 02142, USA.
  • Winnicki S; Broad Institute, Cambridge, MA 02142, USA.
  • Reilly SK; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Andersen KG; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA.
  • Mikkelsen TS; Broad Institute, Cambridge, MA 02142, USA.
  • Lander ES; Broad Institute, Cambridge, MA 02142, USA.
  • Schaffner SF; Broad Institute, Cambridge, MA 02142, USA.
  • Sabeti PC; Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address: pardis@broadinstitute.org.
Cell ; 165(6): 1519-1529, 2016 Jun 02.
Article en En | MEDLINE | ID: mdl-27259153
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Regulación de la Expresión Génica / Técnicas Genéticas / Genes Reporteros / Enfermedades Genéticas Congénitas Tipo de estudio: Diagnostic_studies / Evaluation_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Regulación de la Expresión Génica / Técnicas Genéticas / Genes Reporteros / Enfermedades Genéticas Congénitas Tipo de estudio: Diagnostic_studies / Evaluation_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cell Año: 2016 Tipo del documento: Article