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Identification of potent and selective retinoic acid receptor gamma (RARγ) antagonists for the treatment of osteoarthritis pain using structure based drug design.
Hughes, Norman E; Bleisch, Thomas J; Jones, Scott A; Richardson, Timothy I; Doti, Robert A; Wang, Yong; Stout, Stephanie L; Durst, Gregory L; Chambers, Mark G; Oskins, Jennifer L; Lin, Chaohua; Adams, Lisa A; Page, Todd J; Barr, Robert J; Zink, Richard W; Osborne, Harold; Montrose-Rafizadeh, Chahrzad; Norman, Bryan H.
Afiliación
  • Hughes NE; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Bleisch TJ; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Jones SA; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Richardson TI; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Doti RA; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Wang Y; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Stout SL; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Durst GL; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Chambers MG; Musculoskeletal Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Oskins JL; Musculoskeletal Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Lin C; Musculoskeletal Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Adams LA; Toxicology/Drug Disposition, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Page TJ; Toxicology/Drug Disposition, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Barr RJ; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Zink RW; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Osborne H; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Montrose-Rafizadeh C; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States.
  • Norman BH; Discovery Chemistry Research and Technologies, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States. Electronic address: norman@lilly.com.
Bioorg Med Chem Lett ; 26(14): 3274-3277, 2016 07 15.
Article en En | MEDLINE | ID: mdl-27261179
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Dolor / Piperazinas / Pirazoles / Diseño de Fármacos / Receptores de Ácido Retinoico Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoartritis / Dolor / Piperazinas / Pirazoles / Diseño de Fármacos / Receptores de Ácido Retinoico Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos